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Contribution of the gene linked to the T cell receptor β chain gene complex of NZW mice to the autoimmunity of (NZB × NZW)F 1 mice
Author(s) -
Hirose Sachiko,
Tokushige Katsutoshi,
Kinoshita Kohji,
Nozawa Shingo,
Saito Juichi,
Nishimura Hiroyuki,
Shirai Toshikazu
Publication year - 1991
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830210343
Subject(s) - biology , congenic , t cell receptor , autoimmunity , autoantibody , gene , autoimmune disease , immunology , histone , antibody , microbiology and biotechnology , t cell , genetics , immune system
Abstract We have investigated the contribution to the autoimmune disease of (NZB × NZW)F 1 (NZB/W) mice made by the T cell receptor β (TcR β) chain gene complex, or genes linked to it, that are derived from the NZW strain. For this, we developed the NZW.TcR β NZB strain, a NZW congenic line carrying the TcR β of NZB type, and produced NZB × NZW.TcR β NZB (NZB/W.TcR β NZB )F 1 mice. We compared the amounts of anti‐DNA and anti‐histone antibodies and also the severity of lupus nephritis in these mice with those in the original NZB/W F 1 mice. We obtained evidence for significantly lower serum levels of autoantibodies to double‐stranded and single‐stranded DNA and histone, and a later onset and a lower incidence of proteinuria in the NZB/W.TcR β NZB F 1 mice than in the original NZB/W F 1 mice. These findings clearly indicate that the gene (s) within or closely linked to the TcR β chain gene complex on chromosome 6 of the NZW strain acts to intensify the feature of systemic lupus erythematosus in the NZB/W F 1 strain. The significant relationship of this finding to the strict dependency of NZB/W F 1 disease on the H2 d /H2 z heterozygosity is discussed.