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Selective death of T cell receptor γ/δ + intraepithelial lymphocytes by apoptosis
Author(s) -
Viney Joanne L.,
Macdonald Thomas T.
Publication year - 1990
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830201242
Subject(s) - t cell receptor , biology , intraepithelial lymphocyte , apoptosis , programmed cell death , immunology , epithelium , receptor , t cell , microbiology and biotechnology , cell , cancer research , immune system , genetics
Abstract In mice, the majority of Tcells expressing the γ/δ Tcell receptor (TcR) are found at mucosal surfaces, especially the intestinal epithelium. Here we show that in vitro , the majority of TcR γ/δ + intraepithelial lymphocytes, but not TcR α/β + intraepithelial lymphocytes, undergo rapid and selective programmed cell death by apoptosis.