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A new cell surface molecule closely related to mouse class i transplantation antigens
Author(s) -
Cochet Madeleine,
Casrouge Armanda,
Dumont AnneMarie,
Transy Catherine,
Baleux FrançOise,
Maloy W. Lee,
Coligan John E.,
Cazenave PierreAndré,
Kourilsky Philippe
Publication year - 1989
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830191025
Subject(s) - biology , gene , microbiology and biotechnology , transfection , antigen , transplantation , glycoprotein , splenocyte , genetics , medicine , surgery
Abstract The “37” H‐2 class I mouse gene, located in the Tla complex, is poorly polymorphic and is transcribed in a wide variety of cells and tissues. Using antisera directed against peptides deduced from the gene sequence, we demonstrate that the 37 gene encodes a 45.5‐kDa cell surface glycoprotein. This protein, initially identified on the surface of mouse L cells transfected with an overexpressing 37 gene, is present on cells such as splenocytes of various mouse strains except those of A/J mice. Thus, mouse cells may express not only the major transplantation antigens encoded by the K and D region genes, but at least one additional poorly polymorphic class I molecule encoded by the 37 gene.