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A V H gene is located within 95 Kb of the human immunoglobulin heavy chain constant region genes
Author(s) -
Buluwela Lakjaya,
Rabbitts Terence H.
Publication year - 1988
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830181130
Subject(s) - biology , gene , immunoglobulin heavy chain , constant (computer programming) , antibody , genetics , heavy chain , microbiology and biotechnology , chain (unit) , immunoglobulin light chain , physics , astronomy , computer science , programming language
Abstract Using cosmids covering about 117 Kb upstream of the human immunoglobulin chain C, gene, we have identified a potentially functional VH gene, belonging to the V H VI subgroup. This V H VI gene is only about 95 Kb from the C μ gene and is probably the first functional VH segment of the Igh locus. These results illustrate the proximity of the human V H , D H and J H segments involved in creation of the complete heavy chain genes.