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Specific lysis by CD8 + T cells of Schwann cells expressing Mycobacterium leprae antigens
Author(s) -
Steinhoff Ulrich,
Kaufmann Stefan H. E.
Publication year - 1988
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830180622
Subject(s) - mycobacterium leprae , biology , antigen , cytotoxic t cell , priming (agriculture) , cd8 , microbiology and biotechnology , interferon gamma , major histocompatibility complex , in vitro , immunology , immune system , leprosy , biochemistry , botany , germination
Abstract In vitro cultured murine Schwann cells which were devoid of class I and class II gene products of the major histocompatibility complex expressed class I, though not class 11, antigens after stimulation with recombinant interferon‐γ. Recombinant 1FN‐γ‐stimulated Schwann cells after priming with M. leprue were lysed by antigen‐specific CD8 + T lymphocytes in vitro. These findings suggest that specific lysis of M. leprae‐ infected Schwann cells by CD8 + CTL plays a role in leprosy.