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Prolonged growth of activated B lymphocytes requires interaction with helper T cells
Author(s) -
Rajasekar Ramanujam,
Andersson Jan,
Leanderson Tomas
Publication year - 1987
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830171115
Subject(s) - biology , microbiology and biotechnology , t cell , immunology , t helper cell , b cell , in vitro , immune system , antibody , biochemistry
Abstract Resting B lymphocytes acquire upon activation responsiveness to soluble factors that support their growth and differentiation. We have studied the growth requirements of anti‐μ pre‐activated B lymphocytes in vitro . We found that activated B lymphocytes did respond to soluble factors from helper T cells by entering the cell cycle but cell‐cell contact with specific helper T cells was required for prolonged growth of activated B lymphocytes. Thus, activated B lymphocytes must receive activation signals from helper T cells in order to stay in the proliferative phase of the cell cycle.