Premium
Autoreactive or self restricted?
Author(s) -
Julius Michael H.,
Heusser Christoph H.
Publication year - 1986
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830160726
Subject(s) - biology , major histocompatibility complex , antigen , immunology , population , t cell , mhc restriction , mhc class ii , genetics , mhc class i , immune system , demography , sociology
Abstract Putative major histocompatibility complex (MHC) class II‐specific T cell clones were isolated from nominal antigen‐primed T cell populations propagated in vitro under antigen selection. However, unlike the proliferative responses of nominal antigen‐specific, MHC class II‐restricted T cell clones derived from the same population, the former's MHC‐specific proliferative responses required that the culture medium be supplemented with serum. The role of xenogeneic antigens in the generation of this category of “autoreactive” T cells is discussed.