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Content of a cross‐reactive idiotype in nonimmune A/J sera
Author(s) -
Barrett Mary C.,
Nisonoff Alfred
Publication year - 1982
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830121115
Subject(s) - idiotype , radioimmunoassay , biology , cross reactions , antibody , microbiology and biotechnology , immunology , biochemistry , monoclonal antibody
Abstract The anti‐p‐azophenylarsonate antibodies of A/J mice express a major intrastrain cross‐reactive idiotype (CRI A ). Using a sensitive radioimmunoassay we were unable to detect significant quantities of molecules bearing CRI A in nonimmune A/J sera. The upper limit is 140 ng/ml. Possible reasons for variability of such data in the published literature are discussed.