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Cyclosporin A mediates immunosuppression of primary cytotoxic T cell responses by impairing the release of interleukin 1 and interleukin 2
Author(s) -
Bunjes Donald,
Hardt Conny,
Röllinghoff Martin,
Wagner Hermann
Publication year - 1981
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830110812
Subject(s) - cytotoxic t cell , interleukin 2 , biology , immunosuppression , immunology , interleukin , in vitro , interleukin 3 , immunosuppressive drug , pharmacology , cytokine , interleukin 21 , transplantation , medicine , biochemistry
Abstract The site of action of the immunosuppressive drug cyclosporin A in in vitro cytotoxic allograft responses has been localized. General cytotoxic effects of the drug on proliferating T cells became apparent at concentrations of 500–1000 ng/ml, while selective effects were observed at concentrations of 10–100 ng/ml. The selective effects included a blockade of interleukin 2 release from activated T helper cells on the one hand and inhibition of interleukin 1 release from splenic adherent cells on the other. While cyclosporin A did not interfere with the intracellular events required for the activation and subsequent clonal expansion of alloreactive T cells, the lack of interleukin 1 and interleukin 2 induced by cyclosporin A results in an inability of T responder cells to mount cytotoxic allograft responses in vitro .