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Regulation of ongoing IgE antibody responses with minute doses of antigen
Author(s) -
Jarrett Ellen E. E.,
Hall Elizabeth
Publication year - 1981
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830110615
Subject(s) - effector , biology , immunoglobulin e , antigen , immunology , antibody , stimulus (psychology) , psychology , psychotherapist
Abstract Repeated challenge of egg albumin‐immunized Hooded Lister rats with a tiny amount of antigen presents a stimulus not only to effector cells for an IgE response but also to a related class‐selective suppressive mechanism which eventually becomes predominant. The results obtained suggest that IgE responsiveness is abrogated by exposure to an antigen dose which is several orders of magnitude lower than required for the regulation of antibody of other classes.