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Stimulation of regulatory T cell circuits by immunoglobulin‐dependent structures on activated B cells
Author(s) -
L'ageStehr Johanna,
Teichmann Hans,
Gershon Richard K.,
Cantor Harvey
Publication year - 1980
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830100105
Subject(s) - biology , surface immunoglobulin , antibody , b cell , cell , stimulation , suppressor , t cell , microbiology and biotechnology , immunology , immune system , neuroscience , gene , biochemistry
Abstract An immunoregulatory circuit is described in which B cell blasts activate syngeneic Ly‐1 + 2 − 3 − T cells to (a) start a reaction which is indistinguishable from a graft‐ vs. ‐ host reaction (syngeneic GvH) and (b) induce suppressor cell activity which abrogates the syngeneic GvH. Since capping the surface immunoglobulin (Ig) on B cell blasts blocks their ability to activate this circuit, it is likely that the relevant cell surface structure “seen” on the B cell by the Ly‐1 T cell is either Ig itself or another molecule in association with Ig.