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Identification of TL + thymocytes with different Lyt phenotypes
Author(s) -
Kisielow Paweł,
Dráber Petr,
Wysocka Maria
Publication year - 1979
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830091220
Subject(s) - biology , phenotype , cytotoxic t cell , antiserum , immunology , antigen , thymocyte , microbiology and biotechnology , genetics , in vitro , cd8 , gene
Abstract The surface antigenic phenotype of BALB/c thymocytes has been analyzed by sequential cytotoxic treatment with Lyt‐1.2, Lyt‐2.2 and TL.2 antisera plus complement. Two new minor subpopulations with TL + Lyt‐l + 2 − and TL + Lyt‐l − 2 + phenotypes have been identified providing direct evidence for the heterogeneity of the Lyt phenotype among the TL‐positive supopulation of thymocytes. This finding suggests that differentiation pathways of Lyt subsets of T cells are more complex than originally proposed and that commitment to separate lines of differentiation may occur already at the level of immature, cortical thymocytes.