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Immunologically active zones in bovine growth hormone
Author(s) -
Ferrara Pascual,
Zakin Mario M.,
Peña Clara,
Paladini Alejandro C.
Publication year - 1979
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830091219
Subject(s) - biology , bovine somatotropin , disulfide bond , antigen , hormone , growth hormone , sequence (biology) , biochemistry , immunology
Abstract Antigenic determinant areas were detected in bovine growth hormone fragments 6–124 and 125–149, the former being predominant. Reduction and carboxymethylation of disulfide bridge 53–164 destroys the immunological reactivity of the area which is little affected by reduction and carbamoylmethylation. All the activity found in fragment 6–124 seems to be concentrated in the sequence 87–124.