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Differential sensitivity of memory cell subpopulations to anti‐immunoglobulin and complement
Author(s) -
Potash Mary Jane,
Knopf P. M.
Publication year - 1978
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830081008
Subject(s) - biology , antiserum , isotype , immunology , antibody , adoptive cell transfer , immunoglobulin g , microbiology and biotechnology , t cell , immune system , monoclonal antibody
Abstract Evidence is presented for the unique sensitivity of memory cells bearing surface immunoglobulin G 1 (IgG 1 ) to functional elimination with anti‐immunoglobulin (anti‐Ig) sera and complement (C). Treatment of cells for adoptive transfer with C and anti‐γ 1 , anti‐ K , or anti‐Ig significantly reduces the number of plaque‐forming cells (PFC) of only the IgG 1 isotype found in adoptive recipients. An increase in PFC of other isotypes accompanies the decrease in IgG 1 PFC; there is no net change in the total PFC response. The depletion of IgG 1 PFC requires treatment of transferred cells with both specific antisera and C; antisera directed against other isotypes show no significant effects. The maintenance of the magnitude of PFC response, compensation, is discussed.