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Activation of the alternative complement pathway by human B cell lymphoma lines is associated with Epstein‐Barr virus transformation of the cells
Author(s) -
McConnell I.,
Klein G.,
Lint T. F.,
Lachmann P. J.
Publication year - 1978
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830080702
Subject(s) - alternative complement pathway , biology , epstein–barr virus , complement system , lymphoma , cell culture , virus , in vitro , virology , in vivo , cell , classical complement pathway , microbiology and biotechnology , transformation (genetics) , b cell , cancer research , immunology , gene , genetics , antibody
Abstract Activation of the alternative complement pathway by human B cell lymphoma lines is correlated with the presence of Epstein Barr virus (EBV) in the cell genome. EBV‐negative B cell lymphoma lines produce little activation of the alternative pathway as measured either by C3 deposition on the cell surface or C3 conversion and consumption of alternative pathway activity in the supernatant serum. By contrast, EBV‐positive sublines derived by in vitro EBV conversion of EBV‐negative parental lines produce considerable activation of the alternative pathway. This membrane‐associated complement‐activating mechanism reflects an EBV‐induced membrane change in these cells and may provide a mechanism where by EBV‐transformed cells are controlled in vivo .