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Suppressor T cells in low zone tolerance II. Characterization of suppressor T and amplifier cells by physical and serological methods
Author(s) -
Heuer J.,
Stumpf R.,
Kölsch E.,
Shen F.W.,
Hämmerling G.J.
Publication year - 1977
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830071105
Subject(s) - suppressor , biology , serology , ficoll , microbiology and biotechnology , immunology , genetics , antibody , peripheral blood mononuclear cell , in vitro , cancer
Abstract Suppressor cells involved in low zone tolerance to bacteriophage fd have been characterized by serological and physical methods. Suppressor T cells are peripheral T 2 cells which are Ly‐1 ‐ , Ly‐2 + and Ia + . They are of high electrophoretic mobility, sediment 5 mm/h at 1 × g in a linear Ficoll 70 gradient, but are not restricted to a distinct band in a discontinuous bovine serum albumin gradient. Adherent phagocytic cells of low electrophoretic mobility can act as amplifier cells with a much shorter half‐life than suppressor T cells.