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Study of two different subpopulations of anti‐acetylcholine receptor antibodies in a rabbit with experimental autoimmune myasthenia gravis
Author(s) -
Zurn Anne D.,
Fulpius B.W.
Publication year - 1977
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830070807
Subject(s) - myasthenia gravis , acetylcholine receptor , torpedo , antibody , biology , acetylcholine , receptor , neuromuscular junction , immunology , rabbit (cipher) , endocrinology , biochemistry , neuroscience , statistics , mathematics
Abstract Two different subpopulations of anti‐acetylcholine receptor antibodies were studied during the evolution of experimental autoimmune myasthenia in one rabbit immunized with Torpedo acetylcholine receptor. The results show that the subpopulation of antibodies directed against the toxin‐binding site of the receptor might play a role in the appearance of the paralysis observed in this particular case.