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T lineage lymphocytes in nude mice born from homozygous nu/nu parents
Author(s) -
Loor F.,
Amstutz Heidi,
Hägg LenaBritt,
Mayor Kathleen S.,
Roelants G. E.
Publication year - 1976
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830060914
Subject(s) - lineage (genetic) , spleen , biology , microbiology and biotechnology , nude mouse , immunology , genetics , gene , cell culture
Abstract T lineage cells are found in the spleen of neonatal nu/nu mice born from nu/nu x nu/nu matings, and also in old, healthy nude mice obtained from the usual nu/+ x nu/nu matings. Their presence in neonatal nude mice which were never in contact with mother or normal littermate thymus products shows that commitment of stem cells towards the T lineage does not require the influence of the thymus.