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Premium Idiotype suppression. II. Amplification of a suppressor T cell with anti‐idiotypic activity
Author(s)
Eichmann K.
Publication year1975
Publication title
european journal of immunology
Resource typeJournals
PublisherWILEY‐VCH Verlag GmbH
Abstract Guinea pig IgG 2 anti‐idiotypic antibody (āId2) against the strain A/J antibody A5A has a suppressive effect on the expression of the A5A idiotype in adult A/J mice immunized with Group A streptococci. High doses of āId2 cause an immediate but transient suppression, whereas low doses of āId2 result in a delayed but chronic suppression which lasted for more than 1 year without any indication of recovery. Chronic suppression is transferred by as few as 10 5 spleen cells, but an interval of 6 weeks after transfer is required for completion of suppression. The suppressive capacity of āId2‐induced suppressor cells was virtually inexhaustable in 4 consecutive transfers spaced at 3 month intervals. The suppressor cell is a T cell which adheres to histamine‐rabbit serum albumin‐Sepharose 2B columns.
Subject(s)antibody , biology , cell , endocrinology , gene , genetics , histamine , idiotype , immunoglobulin idiotypes , immunology , medicine , microbiology and biotechnology , monoclonal antibody , spleen , suppressor
Language(s)English
SCImago Journal Rank2.272
H-Index201
eISSN1521-4141
pISSN0014-2980
DOI10.1002/eji.1830050802

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