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Isolation and properties of a 7 S rat immunoglobulin different from IgG
Author(s) -
Binaghi R. A.,
BoussacAron Yolande
Publication year - 1975
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830050308
Subject(s) - biology , antibody , immunoglobulin e , immunoglobulin g , immunology , immunoglobulin m , isolation (microbiology) , microbiology and biotechnology
Abstract A 7 S rat immunoglobulin, of rapid electrophoretic mobility, was characterized and isolated from normal or hyperimmune rat serum and was designated “IgR”. This immunoglobulin belongs to a class different from IgG and was originally described as IgA. IgR has a molecular weight of 160 000, is present in the serum and milk as a monomer and is readily absorbed by the intestine of suckling rats. In hyperimmunized animals, about 20 % of the antibodies were of the IgR class. IgR is devoid of anaphylactic capacity and no homologies could be established between it and immunoglobulins of other animal species.