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Adjuvant activity of bacterial peptidoglycans on the production of delayed hypersensitivity and on antibody response
Author(s) -
Nauciel C.,
Fleck Jacqueline,
Martin J.P.,
Mock Michele,
NguyenHuy H.
Publication year - 1974
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830040509
Subject(s) - adjuvant , peptidoglycan , biology , antibody response , antigen , freund's adjuvant , delayed hypersensitivity , microbiology and biotechnology , antibody , immunology , bacteria , guinea pig , genetics , endocrinology
Abstract Purified peptidoglycans from various gram‐negative bacteria can substitute for mycobacteria in Freund's type adjuvant. The effect of adjuvants on the production of delayed hypersensitivity in the guinea pig was studied with azobenzenearsonateNacetyl L tyrosine as antigen. It was found that only a few μg of peptidoglycan per animal were needed. An adjuvant effect on antibody response to egg albumin was also obtained.