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Immunological responses of guinea pigs to a synthetic autoantigen of brain
Author(s) -
Len Vanda A.,
Carnegie P. R.
Publication year - 1974
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830040116
Subject(s) - biology , immune system , myelin basic protein , peptide , experimental autoimmune encephalomyelitis , guinea pig , immunology , encephalomyelitis , myelin , macrophage , microbiology and biotechnology , biochemistry , in vitro , endocrinology , central nervous system , multiple sclerosis
Abstract A synthetic peptide, Ser‐Arg‐Phe‐Ser‐Trp‐Gly‐Ala‐Glu‐Gly‐Gln‐Arg, of identical sequence to residues 112 to 122 of the basic protein of human myelin was active in guinea pigs in inducing experimental autoimmune encephalomyelitis. This peptide did not induce a humoral immune response, but a cellular immune response was obtained, as judged by transformation of splenic lymphocytes when these were cultured with the human encephalitogenic protein, and by demonstration of macrophage inhibitory factor when peritoneal exudate cells were incubated with the protein.