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Cytotoxic activity of antibodies to a collagen‐like synthetic polytripeptide on cells in tissue culture
Author(s) -
Maoz A.,
Dym H.,
Fuchs Sara,
Sela M.
Publication year - 1973
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830031219
Subject(s) - cytotoxic t cell , biology , antiserum , antibody , tissue culture , microbiology and biotechnology , cell culture , immunology , biochemistry , in vitro , genetics
Abstract Antibodies to the ordered collagen‐like synthetic polymer (Pro‐Gly‐Pro) n , as well as antiserum to rat tail collagen, have a similar specific cytotoxic activity on primary cultures of rat muscle cells and on rat embryo fibroblasts. This cytotoxic effect is complement‐dependent, and could be observed both in monolayers and in cell suspensions.