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Thymus reticulum cell cultures confer T cell properties on spleen cells from thymus‐deprived animals
Author(s) -
Wekerle H.,
Cohen I. R.,
Feldman M.
Publication year - 1973
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830031202
Subject(s) - immunocompetence , biology , spleen , endoplasmic reticulum , lymphocyte , function (biology) , in vitro , microbiology and biotechnology , t lymphocyte , reticulum , immunology , immune system , biochemistry
Abstract The development of T lymphocyte immunocompetence appears to depend upon the function of the thymus gland. To study this function in greater detail, we developed a method for preparing monolayer cultures of thymus reticulum cells. We found that populations of lymphocytes from thymus‐deprived mice acquired the ability to produce T lymphocyte reactions when incubated with reticulum cells in vitro. These results provide evidence about the role of the thymus reticulum in inducing immunocompetence of T lymphocytes.