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The failure to transfer the NZB disease following implantation of NZB thymus‐containing chambers
Author(s) -
Tuffrey Maureen,
Kingman Jean,
Barnes R. D.
Publication year - 1973
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830030814
Subject(s) - biology , disease , immunology , pathology , medicine
Abstract The role of the thymus in the disease of the NZB still remains to be clearly defined. Upon the basis of Coombs' positive reactions occurring in normal strains of mice following the implantation of thymus‐containing diffusion chambers, previous workers suggested the primary role of a subcellular thymus causal factor in the disease of the NZB. We have been unable to confirm these findings in neonatally and adult thymectomized or intact mice of two other strains in spite of being implanted with NZB thymus‐containing chambers.