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The lipid A immunity system. I. Induction of heterophile antibodies by enterobacterial lipopolysaccharides and their lipid A component
Author(s) -
Rank W.R.,
Dipauli R.,
FlüggeRank U.
Publication year - 1972
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830020610
Subject(s) - lipid a , heterophile , biology , antibody , immune system , microbiology and biotechnology , salmonella , escherichia coli , immunity , humoral immunity , shigella , immunology , bacteria , lipopolysaccharide , biochemistry , genetics , gene
Abstract Mice were immunized either with lipopolysaccharides (LPS) or with the respective lipid A components. After four days an increase in the number of direct plaque‐forming cells with complement‐dependent antibody against sheep red cells was seen. Cross‐reactions were observed with red cells of cattle, goats, horses and rabbits. All LPS investigated, of Shigella , Escherichia coli , and S and R form Salmonella , as well as the lipid A component evoked this immune response. We therefore conclude that all enterobacterial LPS induce an antibody which cross‐reacts with SRC and that the lipid A component is responsible for this reaction. Evidence is presented that these effects, such as toxicity, fever, pyrogen tolerance, leucopenia/leucocytosis, nonspecific immunity, and tumor inhibition are mediated by lipid A‐induced antibodies.