Premium
Helper activity of histocompatibility antigens on cell‐mediated immunity
Author(s) -
Di Marco A. T.,
Franceschi C.,
Prodi G.
Publication year - 1972
Publication title -
european journal of immunology
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.272
H-Index - 201
eISSN - 1521-4141
pISSN - 0014-2980
DOI - 10.1002/eji.1830020309
Subject(s) - antigen , histocompatibility , biology , immunology , major histocompatibility complex , immune tolerance , immunity , immune system , skin grafting , cell mediated immunity , pan t antigens , cell , antibody , genetics , human leukocyte antigen , medicine , surgery , monoclonal antibody
Abstract Attempts have been made to provoke a cell‐mediated response toward nonimmunogenic antigens by the provision of additional histoincompatibilities on the same cell. An immunological response has been obtained in a skin grafting system, the male‐to‐female combination in Lewis (L) inbred rats in which non‐reaction has always been observed, by sensitizing L female hosts with (F 344 x Lewis)F 1 male skin grafts. A premature break of the tolerance induced in L rats to F 344 antigens was also obtained by sensitizing tolerant recipients with (F 344 x Bf)F 1 homograft. This hybrid's helper effect, which also occurs when the provision of weak histoincompatibilities is tested, requires the involved antigens to be present on the same cell , and the recipients to be capable of reacting against helping antigens.