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Acute kidney injury in cardiogenic shock: definitions, incidence, haemodynamic alterations, and mortality
Author(s) -
Tarvasmäki Tuukka,
Haapio Mikko,
Mebazaa Alexandre,
Sionis Alessandro,
SilvaCardoso José,
Tolppanen Heli,
Lindholm Matias Greve,
Pulkki Kari,
Parissis John,
Harjola VeliPekka,
Lassus Johan
Publication year - 2018
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.958
Subject(s) - medicine , acute kidney injury , cardiogenic shock , interquartile range , creatinine , renal function , odds ratio , cardiology , confidence interval , population , mean arterial pressure , blood pressure , myocardial infarction , heart rate , environmental health
Aims To investigate the incidence, haemodynamic alterations and 90‐day mortality of acute kidney injury (AKI) in patients with cardiogenic shock. We assessed the utility of creatinine, urine output (UO) and cystatin C (CysC) definitions of AKI in prognostication. Methods and results Cardiogenic shock patients with serial plasma samples ( n = 154) from the prospective multicenter CardShock study were included in the analysis. Acute kidney injury was defined and staged according to the KDIGO criteria by creatinine (AKI crea ) and/or UO (AKI UO ). CysC‐based AKI (AKI CysC ) was defined similarly to AKI crea . Changes in haemodynamic parameters were assessed over time from baseline until 96 h. Mean age of the study population was 66 ± 12 years and 74% were men. Median baseline creatinine was 1.12 [interquartile range (IQR) 0.87–1.54] mg/dL and CysC 1.19 (IQR 0.90–1.69) mg/L. The 90‐day mortality was 38%. The incidences for AKI were: AKI crea 31%, AKI UO 50%, and AKI Cysc 33%. AKI crea [odds ratio (OR) 12.2, 95% confidence interval (CI) 4.1–36.0] and AKI CysC (OR 2.5, 95% CI 1.1–6.1), but not AKI UO , were independent predictors of mortality. However, a stricter UO cut‐off of <0.3 mL/kg/h for 6 h was independently associated with 90‐day mortality (OR 3.6, 95% CI 1.4–9.3). Development of AKI was associated with persistently elevated central venous pressure and decreased cardiac index and mean arterial pressure. Conclusions Acute kidney injury is frequent in patients with cardiogenic shock and especially AKI crea predicts poor outcome. The KDIGO UO criterion seems, however, rather liberal and a stricter AKI definition of UO <0.3 mL/kg/h for at least 6 h seems more useful for mortality risk prediction. Haemodynamic alterations reflecting venous congestion and hypoperfusion were associated with AKI.