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Young Investigator Award: Clinical
Author(s) -
Frank P. Brouwers,
Rudolf A. de Boer,
; Damman,
Marten van den Berg,
Ronald Gansevoort,
JL Hillege,
Dirk van Veldhuisen,
van der Pim Harst,
; Wh,
van Wiekert Gilst,
Stefania Paolillo,
; Limongelli,
; Masarone,
; Salvioni,
; Magri,
L Cas,
; Passantino,
; Pacileo,
Pasquale PerroneFilardi,
; Agostoni
Publication year - 2014
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.93_8
Subject(s) - citation , medicine , library science , heart failure , cardiology , computer science
Background—Inflammatory bowel disease (IBD) has been linked to adverse cardiovascular events, but a relation to heart failure (HF) is uncertain. We investigated the IBD-associated risk of HF in a nationwide setting. Methods and Results—A total of 5 436 647 Danish citizens, with no history of IBD or HF, were included on January 1, 1997, and followed up until first hospitalization for HF, death, or December 31, 2011. Of these subjects, 23 681 developed IBD for which disease activity was determined continuously throughout the study. The risk of hospitalization for HF was estimated with a Poisson regression model adjusting for comorbidity and cardiovascular pharmacotherapy as time-dependent covariates. During a mean follow-up of 11.8 years in the reference population and 6.4 years in the IBD group, hospitalization for HF occurred in 553 subjects with IBD and 171 405 in the reference population. Patients with IBD had a 37% increased risk of hospitalization for HF (incidence rate ratio, 1.37; 95% confidence int...