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Mediterranean diet and risk of heart failure: results from the PREDIMED randomized controlled trial
Author(s) -
Papadaki Angeliki,
MartínezGonzález Miguel Ángel,
AlonsoGómez Angel,
Rekondo Javier,
SalasSalvadó Jordi,
Corella Dolores,
Ros Emilio,
Fitó Montse,
Estruch Ramon,
Lapetra José,
GarcíaRodriguez Antonio,
Fiol Miquel,
SerraMajem Lluís,
Pintó Xavier,
RuizCanela Miguel,
Bulló Monica,
SerraMir Mercè,
Sorlí Jose V.,
Arós Fernando
Publication year - 2017
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.750
Subject(s) - medicine , mediterranean diet , hazard ratio , randomized controlled trial , incidence (geometry) , heart failure , confidence interval , olive oil , food science , chemistry , physics , optics
Aims The aim of this study was to evaluate the effect of the Mediterranean diet (MedDiet) on the incidence of heart failure (HF), a pre‐specified secondary outcome in the PREDIMED (PREvención con DIeta MEDiterránea) primary nutrition‐intervention prevention trial. Methods and results Participants at high risk of cardiovascular disease were randomly assigned to one of three diets: MedDiet supplemented with extra‐virgin olive oil (EVOO), MedDiet supplemented with nuts, or a low‐fat control diet. Incident HF was ascertained by a Committee for Adjudication of events blinded to group allocation. Among 7403 participants without prevalent HF followed for a median of 4.8 years, we observed 29 new HF cases in the MedDiet with EVOO group, 33 in the MedDiet with nuts group, and 32 in the control group. No significant association with HF incidence was found for the MedDiet with EVOO and MedDiet with nuts, compared with the control group [hazard ratio (HR) 0.68; 95% confidence interval (CI) 0.41–1.13, and HR 0.92; 95% CI 0.56–1.49, respectively]. Conclusion In this sample of adults at high cardiovascular risk, the MedDiet did not result in lower HF incidence. However, this pre‐specified secondary analysis may have been underpowered to provide valid conclusions. Further randomized controlled trials with HF as a primary outcome are needed to better assess the effect of the MedDiet on HF risk. Trial registration: ISRCTN35739639.