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Sex‐specific cardiovascular structure and function in heart failure with preserved ejection fraction
Author(s) -
Gori Mauro,
Lam Carolyn S. P.,
Gupta Deepak K.,
Santos Angela B. S.,
Cheng Susan,
Shah Amil M.,
Claggett Brian,
Zile Michael R.,
KraigherKrainer Elisabeth,
Pieske Burkert,
Voors Adriaan A.,
Packer Milton,
Bransford Toni,
Lefkowitz Martin,
McMurray John J. V.,
Solomon Scott D.
Publication year - 2014
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.67
Subject(s) - medicine , cardiology , ejection fraction , heart failure , heart failure with preserved ejection fraction , concentric hypertrophy , coronary artery disease , diastole , left ventricular hypertrophy , doppler imaging , muscle hypertrophy , ventricular remodeling , diastolic heart failure , blood pressure
Aims Women are more likely to develop heart failure with preserved ejection fraction ( HFpEF ) than men. We studied the relationship between sex and cardiovascular structure and function in patients with HFpEF . Methods and results The study included 279 participants from the PARAMOUNT study (57% women) with analysable baseline echocardiograms (mean age 71 years, 94% hypertensive, 38% diabetic). We assessed sex‐based differences in baseline clinical characteristics and measures of cardiovascular structure/function. Coronary artery disease was less common in women than in men. Women were more obese and symptomatic, and less likely to have albuminuria. Women had higher indexed left ventricular ( LV ) wall thicknesses, worse diastolic function (lower E′, P = 0.002; higher E/E′, P < 0.001), while LV mass and LV volumes indexed for height 2.7 were similar. Nonetheless, female sex was associated with a trend towards higher prevalence of abnormal LV geometry (defined as concentric hypertrophy, or eccentric hypertrophy, or concentric remodelling) at baseline (unadjusted P = 0.028, adjusted P = 0.056) and 12 weeks' follow up (unadjusted P = 0.001, adjusted P = 0.006), but not at 36 weeks' follow up (unadjusted P = 0.81, adjusted P = 0.99). Despite higher LV ejection fraction in women, global LV strain was similar between the sexes, while Tissue Doppler Imaging S′ mitral velocity was lower in women. Both LV diastolic and systolic stiffness were higher in women than men ( P < 0.001), even adjusting for LV concentricity and clinical covariates. We observed no sex differences in systolic arterial– LV coupling, as women also had higher absolute arterial elastance compared with men, although this difference was not significant after adjusting for height 2.7 . Conclusion More pronounced diastolic dysfunction may contribute to the greater predisposition for HFpEF in women compared with men.