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Increased plasma level of soluble urokinase plasminogen activator receptor is associated with incidence of heart failure but not atrial fibrillation
Author(s) -
Borné Yan,
Persson Margaretha,
Melander Olle,
Smith J. Gustav,
Engström Gunnar
Publication year - 2014
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.49
Subject(s) - supar , medicine , hazard ratio , heart failure , atrial fibrillation , gastroenterology , incidence (geometry) , cardiology , endocrinology , plasminogen activator , confidence interval , population , urokinase receptor , physics , optics , environmental health
Aims Soluble urokinase plasminogen activator receptor ( suPAR ) in plasma is a novel inflammatory marker thought to be released from the cell surface of neutrophils, T cells, and macrophages. Other inflammatory markers, mainly acute phase proteins produced in the liver, have been associated with the incidence of heart failure ( HF ) and atrial fibrillation (AF). We investigated the association between suPAR and incident HF and AF in a population‐based cohort. Methods and results Soluble urokinase plasminogen activator receptor was measured in 4530 subjects (aged 46–68 years, 61% women), who participated in the Malmö Diet and Cancer study during 1991–1996. Incident cases of HF and AF were identified from the Swedish hospital discharge register during a median follow‐up of 16.3 years. During follow‐up, 109 subjects (55% men) were diagnosed with new‐onset HF and 321 individuals (50% men) with AF . suPAR was significantly associated with increased plasma levels of NT‐proBNP ( P < 0.001). suPAR was significantly associated with incidence of HF [hazard ratio ( HR ) for the third vs. first tertile 3.33, 95% confidence interval ( CI ) 1.91–5.81 after adjustment for age and sex; and HR 1.82, 95% CI 1.02–3.27, P for trend 0.018 after adjustment for conventional risk factors and biomarkers]. suPAR was significantly associated with incidence of AF , when adjusted for age and sex ( HR 1.40, 95% CI 1.06–1.85). However, this relationship was non‐significant after adjustment for conventional risk factors and biomarkers. Conclusion Soluble urokinase plasminogen activator receptor was associated with increased plasma levels of NT‐proBNP and incidence of HF , but not with AF among middle‐aged subjects.