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Lung congestion in chronic heart failure: haemodynamic, clinical, and prognostic implications
Author(s) -
Melenovsky Vojtech,
Andersen Mads J.,
Andress Krystof,
Reddy Yogesh N.,
Borlaug Barry A.
Publication year - 2015
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.417
Subject(s) - medicine , cardiology , heart failure , lung , pulmonary wedge pressure , vascular resistance , interquartile range , pulmonary artery , hemodynamics
Aims The goal of the study was to examine the prognostic impact, haemodynamic and clinical features associated with lung congestion in patients with chronic heart failure ( HF ). Methods and results HF patients ( n = 186) and HF ‐free controls ( n = 21) underwent right heart catheterization, echocardiography, pulmonary function testing and chest radiography that was blindly scored for the presence and severity of lung oedema. Lung congestion correlated directly with pulmonary vascular resistance ( PVR , P = 0.004) and inversely with pulmonary artery ( PA ) compliance ( P < 0.001) and the diffusion limit for carbon monoxide ( DL CO , P = 0.009). Compared with dry lung HF , wet lung HF patients (congestion score > median) had 25% lower PA compliance and 25–35% higher PVR , transpulmonary gradients and PA pressures (40 vs. 32 mmHg , P < 0.001) despite marginally higher PA wedge pressure ( PAWP ; 22 vs. 19 mmHg , P = 0.002). Wet lung HF patients displayed more right ventricular ( RV ) dilatation and dysfunction, more restrictive ventilation and greater reduction of DL CO . The strongest correlates of lung congestion were NT‐proBNP , haemoglobin, albumin, and glomerular filtration, all surpassing PAWP . After a median of 333 days (interquartile range 80–875), 59 patients (32%) died. Lung congestion was associated with reduced survival ( P < 0.0001), even after adjusting for PAWP , NT‐proBNP , anaemia, CAD and renal dysfunction. Conclusion Interstitial lung oedema is associated with pulmonary vascular disease, RV overload and dysfunction and increased mortality in HF . These data reinforce the importance of aggressive decongestion in HF and suggest that novel agents aimed at reducing lung water may help to deter progression of pulmonary vascular disease and biventricular HF .