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The significance of left ventricular ejection time in heart failure with reduced ejection fraction
Author(s) -
Alhakak Alia S.,
Teerlink John R.,
Lindenfeld Joann,
Böhm Michael,
Rosano Giuseppe M.C.,
BieringSørensen Tor
Publication year - 2021
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.2125
Subject(s) - medicine , cardiology , ventricle , heart failure , ejection fraction , contractility , afterload , aorta , systole , blood pressure , diastole
Left ventricular ejection time (LVET) is defined as the time interval from aortic valve opening to aortic valve closure, and is the phase of systole during which the left ventricle ejects blood into the aorta. LVET has been used for several decades to assess left ventricular function and contractility. However, there is a recent interest in LVET as a measure of therapeutic action for novel drugs in patients with heart failure with reduced ejection fraction (HFrEF), since LVET is shortened in these patients. This review provides an overview of the available information on LVET including methods of measuring LVET, mechanistic understanding of LVET, association of LVET with outcomes, mechanisms behind shortened LVET in HFrEF and the potential implications of drugs that affect and normalize LVET.