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Standardized definitions for evaluation of heart failure therapies: scientific expert panel from the Heart Failure Collaboratory and Academic Research Consortium
Author(s) -
Abraham William T.,
Psotka Mitchell A.,
Fiuzat Mona,
Filippatos Gerasimos,
Lindenfeld JoAnn,
Mehran Roxana,
Ambardekar Amrut V.,
Carson Peter E.,
Jacob Richard,
Januzzi James L.,
Konstam Marvin A.,
Krucoff Mitchell W.,
Lewis Eldrin F.,
Piccini Jonathan P.,
Solomon Scott D.,
Stockbridge Norman,
Teerlink John R.,
Unger Ellis F.,
Zeitler Emily P.,
Anker Stefan D.,
O'Connor Christopher M.
Publication year - 2020
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.2018
Subject(s) - collaboratory , medicine , heart failure , general partnership , clinical trial , food and drug administration , clinical endpoint , clinical research , medical education , cardiology , medical emergency , political science , computer science , world wide web , law
The Heart Failure Academic Research Consortium is a partnership between the Heart Failure Collaboratory (HFC) and Academic Research Consortium (ARC), comprised of leading heart failure (HF) academic research investigators, patients, United States (US) Food and Drug Administration representatives, and industry members from the US and Europe. A series of meetings were convened to establish definitions and key concepts for the evaluation of HF therapies including optimal medical and device background therapy, clinical trial design elements and statistical concepts, and study endpoints. This manuscript summarizes the expert panel discussions as consensus recommendations focused on populations and endpoint definitions; it is not exhaustive or restrictive, but designed to stimulate HF clinical trial innovation.