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Regional adiposity and heart failure with preserved ejection fraction
Author(s) -
Rao Vishal N.,
Fudim Marat,
Mentz Robert J.,
Michos Erin D.,
Felker G. Michael
Publication year - 2020
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.1956
Subject(s) - medicine , heart failure , ejection fraction , cardiology , heart failure with preserved ejection fraction
The role of obesity in the pathogenesis of heart failure (HF), and in particular HF with preserved ejection fraction (HFpEF), has drawn significant attention in recent years. The prevalence of both obesity and HFpEF has increased worldwide over the past decades and when present concomitantly suggests an obese‐HFpEF phenotype. Anthropometrics, including body mass index, waist circumference, and waist‐to‐hip ratio, are associated with incident HFpEF. However, the cardiovascular effects of obesity may actually be driven by the distribution of fat, which can accumulate in the epicardial, visceral, and subcutaneous compartments. Regional fat can be quantified using non‐invasive imaging techniques, including computed tomography, magnetic resonance imaging, and dual‐energy X‐ray absorptiometry. Regional variations in fat accumulation are associated with different HFpEF risk profiles, whereby higher epicardial and visceral fat have a much stronger association with HFpEF risk compared with elevated subcutaneous fat. Thus, regional adiposity may serve a pivotal role in the pathophysiology of HFpEF contributing to decreased cardiopulmonary fitness, impaired left ventricular compliance, upregulation of local and systemic inflammation, promotion of neurohormonal dysregulation, and increased intra‐abdominal pressure and vascular congestion. Strategies to reduce total and regional adiposity have shown promise, including intensive exercise, dieting, and bariatric surgery programmes, but few studies have focused on HFpEF‐related outcomes among obese. Further understanding the role these variable fat depots play in the progression of HFpEF and HFpEF‐related hospitalizations may provide therapeutic targets in treating the obese‐HFpEF phenotype.

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