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Systolic blood pressure and mortality in patients with atrial fibrillation and heart failure: insights from the AFFIRM and AF‐CHF studies
Author(s) -
TremblayGravel Maxime,
Khairy Paul,
Roy Denis,
Leduc Hugues,
Wyse D. George,
CadrinTourigny Julia,
Macle Laurent,
Dubuc Marc,
Andrade Jason,
Rivard Lena,
Guerra Peter G.,
Thibault Bernard,
Ahmed Ali,
Talajic Mario,
Guertin MarieClaude,
White Michel
Publication year - 2014
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.168
Subject(s) - medicine , cardiology , hazard ratio , heart failure , blood pressure , ejection fraction , atrial fibrillation , proportional hazards model , confidence interval
Aims To investigate the association between baseline systolic blood pressure levels and mortality in patients with AF with or without LV dysfunction. Hypertension leads to cardiovascular disease but, in specific groups, low blood pressure has been associated with a paradoxical increase in mortality. In patients with AF and heart failure, the relationship between blood pressure and death remains largely unknown. Methods and results We conducted a post‐hoc combined analysis on pooled data from AFFIRM and AF‐CHF trials and assessed the relationship between baseline systolic blood pressure ( SBP ) and mortality and hospitalizations. Patients were classified according to LVEF (>40%, ≤40%) and baseline SBP (<120 mmHg , 120–140 mmHg , >140 mmHg ). A total of 5436 patients with non‐permanent AF were followed for 41 ± 16 months. In patients with LVEF >40%, baseline SBP was not related to mortality using multivariate Cox regression analyses to adjust for baseline differences ( P = 0.563). In contrast, in patients with LVEF ≤40% ( n = 1980), SBP <120 mmHg and SBP >140 mmHg were both associated with a significant increase in total mortality compared with SBP 120–140 mmHg [hazard ratio ( HR ) 1.75, 95% confidence interval ( CI ) 1.41–2.17; and HR 1.40, 95% CI 1.04–1.90, respectively]. Hospitalizations were unrelated to SBP regardless of LVEF . Conclusions Mortality is modulated by baseline SBP levels in patients with AF and depressed EF but not in patients with normal EF . Targeted therapy of AF patients based on SBP merits further prospective investigation.