Premium
Is plasma renin activity associated with worse outcomes in acute heart failure? A secondary analysis from the BLAST‐AHF trial
Author(s) -
Rachwan Rayan Jo,
Butler Javed,
Collins Sean P.,
Cotter Gad,
Davison Beth A.,
Senger Stefanie,
Ezekowitz Justin A.,
Filippatos Gerasimos,
Levy Phillip D.,
Metra Marco,
Ponikowski Piotr,
Teerlink John R.,
Voors Adriaan A.,
Boer Rudolf A.,
Soergel David G.,
Felker G. Michael,
Pang Peter S.
Publication year - 2019
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.1607
Subject(s) - medicine , heart failure , hazard ratio , plasma renin activity , cardiology , confidence interval , proportional hazards model , renal function , blood pressure , renin–angiotensin system
Aims Neurohormonal activation characterizes chronic heart failure (HF) and is a well‐established therapeutic target. Neurohormonal activation may also play a key role in acute HF (AHF). We aim to describe the association between plasma renin activity (PRA) and three AHF outcomes: (i) worsening HF or death through day 5 of hospitalization; (ii) HF rehospitalization or death through day 30; and (iii) all‐cause death through day 30. Methods and results A secondary analysis of the BLAST‐AHF trial was performed. Eligible patients had a history of HF, elevated natriuretic peptides, signs and symptoms of HF, systolic blood pressure >120 mmHg, and an estimated glomerular filtration rate between 20–75 mL/min/1.73 m 2 . The primary trial was neutral, with no differential effect of study drug by PRA levels. Baseline PRA levels were grouped into tertiles. Adjusted Cox proportional hazard model determined the association of PRA levels with outcomes (α set at P < 0.05). Of 618 randomized patients, 578 (93.5%) had a baseline PRA. PRA was modestly, but significantly, associated with each outcome without adjustment [worsening HF or death through day 5: hazard ratio (HR) 1.11, 95% confidence interval (CI) 1.01–1.23, P = 0.04; HF rehospitalization or death through day 30: HR 1.13, 95% CI 1.02–1.26, P = 0.02; all‐cause death through day 30: HR 1.18, 95% CI 1.02–1.37, P = 0.03]. After multivariable adjustment, PRA was only significantly associated with HF rehospitalization or death through day 30 (HR 1.15, 95% CI 1.01–1.32, P = 0.04). Conclusion Baseline PRA levels are associated with increased risk for the composite of 30‐day HF rehospitalization or death in patients with AHF.