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High prevalence of iron deficiency in patients with acute decompensated heart failure
Author(s) -
CohenSolal Alain,
Damy Thibaud,
Terbah Mohamed,
Kerebel Sébastien,
Baguet JeanPhilippe,
Ha Olivier,
Zannad Faiez,
Laperche Thierry,
Leclercq Christophe,
Concas Victor,
Duvillié Ladan,
Darné Bernadette,
Anker Stefan,
Mebazaa Alexandre
Publication year - 2014
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.139
Subject(s) - medicine , heart failure , decompensation , iron deficiency , diabetes mellitus , cardiology , anemia , endocrinology
Aims Limited data are available on iron parameters in patients hospitalized for decompensation of chronic heart failure. Methods and results Iron parameters of patients hospitalized for decompensation of chronic heart failure were prospectively assessed during the 72 h after hospital admission. Iron deficiency was defined according to the 2012 European Society of Cardiology Guidelines. Overall, 411 men (75 ± 12 years; 75% NYHA functional classes III / IV ) and 421 women (81 ± 11 years; 71% NYHA classes III / IV ) were evaluated. The prevalence of iron deficiency was 69% in men and 75% in women (including 41% and 49% with absolute iron deficiency, respectively). The prevalence of anaemia in men (<13 g/ dL ) was 68% and in women (<12 g/ dL ) it was 52%. Among non‐anaemic patients, the prevalence of iron deficiency was 57% in men and 79% in women. Only 9% of patients received iron supplementation at the time of admission (oral, 9%; intravenous, 0.2%). Multivariate analysis showed that anaemia and antiplatelet treatment in men, and diabetes and low C‐reactive protein in women, were independently associated with iron deficiency. Conclusions Iron deficiency is very common in patients admitted for acute decompensated heart failure, even among non‐anaemic patients. Given the benefit of iron therapy in chronic heart failure, our results emphasize the need to assess iron status not only in chronic heart failure patients, but even more so in those admitted for worsening heart failure, regardless of gender, heart failure severity, or haemoglobin level. Initiating iron therapy in hospitalized heart failure patients needs to be investigated.