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An integrative translational approach to study heart failure with preserved ejection fraction: a position paper from the Working Group on Myocardial Function of the European Society of Cardiology
Author(s) -
Lourenço Andre P.,
LeiteMoreira Adelino F.,
Balligand JeanLuc,
Bauersachs Johann,
Dawson Dana,
de Boer Rudolf A.,
de Windt Leon J.,
FalcãoPires Inês,
FontesCarvalho Ricardo,
Franz Stefan,
Giacca Mauro,
HilfikerKleiner Denise,
Hirsch Emilio,
Maack Christoph,
Mayr Manuel,
Pieske Burkert,
Thum Thomas,
Tocchetti Carlo G.,
Brutsaert Dirk L.,
Heymans Stephane
Publication year - 2018
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.1059
Subject(s) - heart failure with preserved ejection fraction , medicine , heart failure , ejection fraction , translational research , position paper , cardiology , perspective (graphical) , position (finance) , function (biology) , intensive care medicine , pathology , computer science , artificial intelligence , finance , evolutionary biology , economics , biology
As heart failure with preserved ejection fraction (HFpEF) rises to epidemic proportions, major steps in patient management and therapeutic development are badly needed. With the current position paper we seek to update our view on HFpEF as a highly complex systemic syndrome, from risk factors and mechanisms to long‐term clinical manifestations. We will revise recent advances in animal model development, experimental set‐ups and basic and translational science approaches to HFpEF research, highlighting their drawbacks and advantages. Directions are provided for proper model selection as well as for integrative functional evaluation from the in vivo setting to in vitro cell function testing. Additionally, we address new research challenges that require integration of higher‐order inter‐organ and inter‐cell communication to achieve a full systems biology perspective of HFpEF.