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Lessons learned in acute heart failure
Author(s) -
Cheema Baljash,
Ambrosy Andrew P.,
Kaplan Rachel M.,
Senni Michele,
Fonarow Gregg C.,
Chioncel Ovidiu,
Butler Javed,
Gheorghiade Mihai
Publication year - 2018
Publication title -
european journal of heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 5.149
H-Index - 133
eISSN - 1879-0844
pISSN - 1388-9842
DOI - 10.1002/ejhf.1042
Subject(s) - medicine , heart failure , intensive care medicine , ejection fraction , clinical trial , pandemic , acute coronary syndrome , covid-19 , myocardial infarction , disease , infectious disease (medical specialty)
Acute heart failure (HF) is a global pandemic with more than one million admissions to hospital annually in the US and millions more worldwide. Post‐discharge mortality and readmission rates remain unchanged and unacceptably high. Although recent drug development programmes have failed to deliver novel therapies capable of reducing cardiovascular morbidity and mortality in patients hospitalized for worsening chronic HF, hospitalized HF registries and clinical trial databases have generated a wealth of information improving our collective understanding of the HF syndrome. This review will summarize key insights from clinical trials in acute HF and hospitalized HF registries over the last several decades, focusing on improving the management of patients with HF and reduced ejection fraction.