Open AccessCardiac MRI predictors of adverse outcomes in adults with a systemic right ventricle
Author(s) -
Lewis Matthew J.,
Van Dissel Alexandra,
Kochav Jonathan,
DiLorenzo Michael P.,
Ginns Jonathan,
ZemerWassercug Noa,
Groenink Maarten,
Mulder Barbara,
Rosenbaum Marlon
Publication year - 2022
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.13745
Subject(s) - medicine , great arteries , cardiology , ventricle , ejection fraction , clinical endpoint , stroke volume , end systolic volume , heart failure , clinical trial
Aims Predicting risk in individuals with a systemic right ventricle (SRV) remains difficult. We assessed the value of cardiac MRI (CMR) for predicting death, heart transplantation (HT), or need for a ventricular assist device (VAD) in adults with D‐transposition of the great arteries (DTGA) post Mustard/Senning and in adults with congenitally corrected transposition of the great arteries (ccTGA) at two large academic centres. Methods and results Between December 1999 and November 2020, 158 adult patients with an SRV underwent CMR. Indexed right ventricular end‐diastolic volume (RVEDVI), indexed right ventricular end‐systolic volume (RVESVI), right ventricular ejection fraction (RVEF), and right ventricular mass (RV mass) were determined by a core laboratory. Receiver operating curves, area under the curve (AUC), and cut‐points maximizing sensitivity and specificity for the endpoint for each CMR parameter were calculated. Over a median of 8.5 years, 21 patients (13%) met a combined endpoint of HT referral, VAD, or death. Each CMR parameter was significantly associated with the endpoint in both cohorts. The AUCs for RVEDVI, RVESVI, RVEF, and RV mass to predict the endpoint were 0.93, 0.90, 0.73, and 0.84 for DTGA and 0.76, 0.74, 0.71, and 0.74 for ccTGA, respectively. Optimized cut‐points for RVEDVI were calculated for DTGA and ccTGA and were 132 and 126 mL/m 2 , respectively. RVEDVI cut‐points were simplified to 130 mL/m 2 for survival analysis, which was significantly associated with survival in both cohorts. Conclusions Cardiac MRI parameters are associated with an increased risk of death, HT, or VAD in patients with an SRV and should be considered to facilitate risk stratification.