Open AccessA decrease in tricuspid regurgitation pressure gradient associates with favorable outcome in patients with heart failure
Author(s) -
Seko Yuta,
Kato Takao,
Morimoto Takeshi,
Yaku Hidenori,
Inuzuka Yasutaka,
Tamaki Yodo,
Ozasa Neiko,
Shiba Masayuki,
Yamamoto Erika,
Yoshikawa Yusuke,
Kitai Takeshi,
Yamashita Yugo,
Iguchi Moritake,
Nagao Kazuya,
Kawase Yuichi,
Morinaga Takashi,
Toyofuku Mamoru,
Furukawa Yutaka,
Ando Kenji,
Kadota Kazushige,
Sato Yukihito,
Kuwahara Koichiro,
Kimura Takeshi
Publication year - 2021
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.13355
Subject(s) - medicine , heart failure , hazard ratio , cardiology , population , confidence interval , environmental health
Aims Although the prognostic impact of the high tricuspid regurgitation pressure gradient (TRPG) has been investigated, the association of the decrease in TRPG during follow‐up with clinical outcomes in heart failure (HF) has not been previously studied. The aim of this study was to investigate the association of a decrease in TRPG between hospitalization and 6 month visit with subsequent clinical outcomes in patients with acute decompensated HF (ADHF). Methods and results Among 721 patients with available TRPG data both during hospitalization and a subsequent 6 month visit, the study population was divided into two groups: a decrease in TRPG group (>10 mmHg decrease at 6 month visit) ( N = 179) and no decrease in TRPG group ( N = 542). The primary outcome measure was a composite of all‐cause death or HF hospitalization. The cumulative 6 month incidence of primary outcome measure was significantly lower in the decrease in TRPG group than in the no decrease in TRPG group (12.2% vs. 18.7%, P = 0.02). After adjusting for confounders, there was a significantly lower risk in decrease in TRPG group than in the no decrease in TRPG group for the measured primary outcome (hazard ratio: 0.56, 95% confidence interval 0.32–0.93, P = 0.02). The lower risk in decrease in TRPG group was not different among the basal TRPG values. Conclusions Heart failure patients with a decrease in TRPG at 6 months after discharge from ADHF hospitalization had lower subsequent risk of all‐cause death and HF hospitalization than those without a decrease in TRPG, regardless of TRPG values.