Open AccessReparative cell therapy for the heart: critical internal appraisal of the field in response to recent controversies
Author(s) -
Povsic Thomas J.,
SanzRuiz Ricardo,
Climent Andreu M.,
Bolli Roberto,
Taylor Doris A.,
Gersh Bernard J.,
Menasché Philippe,
Perin Emerson C.,
Pompilio Giulio,
Atsma Douwe E.,
Badimon Lina,
DeMaria Anthony N.,
Hare Joshua M.,
Henry Timothy D.,
Janssens Stefan,
Kastrup Jens,
Torella Daniele,
Traverse Jay H.,
Willerson James T.,
FernándezAvilés Francisco
Publication year - 2021
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.13256
Subject(s) - introspection , medicine , critical appraisal , field (mathematics) , engineering ethics , perception , heart failure , service (business) , intensive care medicine , alternative medicine , neuroscience , psychology , pathology , cardiology , engineering , cognitive psychology , mathematics , pure mathematics , economy , economics
The concept that cell‐based repair of myocardial injury might be possible was introduced almost two decades ago; however, the field of cardiovascular reparative medicine has been criticized as translation to clinically effective approaches has been slow. The recent retraction of a series of papers has further impacted perception of this area of research. As researchers, clinicians, and teachers in this field, we felt it incumbent to critically appraise the current state of cardiac cell repair, determine what can be learned from past mistakes, and formulate best practices for future work. This special communication summarizes an introspective assessment of what has fallen short, how to prevent similar issues, and how the field might best move forward in the service of science and patients.