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Abstract   Aims  Cardiomyopathies are a heterogeneous group of disorders that increase the risk for atrial fibrillation (AF). The aim of the study is to assess the prevalence of AF, anticoagulation management, and risk of stroke/transient ischaemic attack (TIA) in patients with cardiomyopathy.    Methods and results  Three thousand two hundred eight consecutive adult patients with cardiomyopathy (34.9% female; median age: 55.0 years) were prospectively enrolled as part of the EURObservational Research Programme Cardiomyopathy/Myocarditis Registry. At baseline, 903 (28.2%) patients had AF (29.4% dilated, 27.5% hypertrophic, 51.5% restrictive, and 14.7% arrhythmogenic right ventricular cardiomyopathy,  P  &lt; 0.001). AF was associated with more advanced New York Heart Association class ( P  &lt; 0.001), increased prevalence of cardiovascular risk factors and co‐morbidities, and a history of stroke/TIA ( P  &lt; 0.001). Oral anticoagulation was administered in 71.7% of patients with AF (vitamin K antagonist: 51.6%; direct oral anticoagulant: 20.1%). At 1 year follow‐up, the incidence of cardiovascular endpoints was as follows: stroke/TIA 1.85% (AF vs. non‐AF: 3.17% vs. 1.19%,  P  &lt; 0.001), death from any cause 3.43% (AF vs. non‐AF: 5.39% vs. 2.50%,  P  &lt; 0.001), and death from heart failure 1.67% (AF vs. non‐AF: 2.44% vs. 1.31%,  P  = 0.033). The independent predictors for stroke/TIA were as follows: AF [odds ratio (OR) 2.812,  P  = 0.005], history of stroke (OR 7.311,  P  = 0.010), and anaemia (OR 3.119,  P  = 0.006).    Conclusions  The study reveals a high prevalence and diverse distribution of AF in patients with cardiomyopathies, inadequate anticoagulation regimen, and high risk of stroke/TIA in this population.

esc heart failure

Atrial fibrillation, anticoagulation management and risk of stroke in the Cardiomyopathy/Myocarditis registry of the EURObservational Research Programme of the European Society of Cardiology