Open AccessThe role of B cells in heart failure and implications for future immunomodulatory treatment strategies
Author(s) -
GarcíaRivas Gerardo,
Castillo Elena Cristina,
GonzalezGil Adrian M.,
MaravillasMontero José Luis,
Brunck Marion,
TorresQuintanilla Alejandro,
ElizondoMontemayor Leticia,
TorreAmione Guillermo
Publication year - 2020
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12744
Subject(s) - heart failure , immune system , inflammation , medicine , innate immune system , regulatory b cells , microbiology and biotechnology , immunology , tissue repair , muscle hypertrophy , b cell , antibody , biology
Despite numerous demonstrations that the immune system is activated in heart failure, negatively affecting patients' outcomes, no definitive treatment strategy exists directed to modulate the immune system. In this review, we present the evidence that B cells contribute to the development of hypertrophy, inflammation, and maladaptive tissue remodelling. B cells produce antibodies that interfere with cardiomyocyte function, which culminates as the result of recruitment and activation of a variety of innate and structural cell populations, including neutrophils, macrophages, fibroblasts, and T cells. As B cells appear as active players in heart failure, we propose here novel immunomodulatory therapeutic strategies that target B cells and their products.