Open AccessPeak exercise stroke volume effects on cognitive impairment in community‐dwelling people with preserved ejection fraction
Author(s) -
Sugie Masamitsu,
Harada Kazumasa,
Takahashi Tetsuya,
Nara Marina,
Kawai Hisashi,
Fujiwara Yoshinori,
Ishikawa Joji,
Tanaka Jun,
Koyama Teruyuki,
Kim Hunkyung,
Sengoku Renpei,
Fujimoto Hajime,
Obuchi Shuichi,
Kyo Shunei,
Ito Hideki
Publication year - 2018
Publication title -
esc heart failure
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.787
H-Index - 25
ISSN - 2055-5822
DOI - 10.1002/ehf2.12311
Subject(s) - ejection fraction , medicine , confounding , montreal cognitive assessment , heart failure , cardiology , stroke volume , natriuretic peptide , metabolic equivalent , cognition , cardiac function curve , heart rate , physical therapy , gerontology , cognitive impairment , physical activity , blood pressure , disease , psychiatry
Aims The association of vascular dysfunction and amyloid beta deposition attracted attentions for its relationship with cognitive decline. Previous studies show the correlation between the declined cardiac function and the cognitive impairment. In the present study, we analysed the association between cognitive functions and cardiac parameters in community‐dwelling people with preserved ejection fraction without heart failure. Methods and results Subjects were 108 Japanese community‐dwelling middle‐aged and older adults with preserved ejection fraction (25 men and 83 women; mean age 74.7 years). Cardiac functional parameters at rest were assessed with B‐type natriuretic peptide and echocardiography. The cardiopulmonary exercise test was used to test these parameters during exercise. Cognitive function was assessed with the Japanese version of the Montreal Cognitive Assessment (MoCA‐J). Other indices were assessed biochemically, physiologically, and physically. There were significant correlations between MoCA‐J score and age ( r = −0.388), peak oxygen uptake (VO 2 , r = 0.201), peak VO 2 /heart rate (HR, r = 0.243), peak VO 2 /weight ( r = 0.244), peak metabolic equivalents ( r = 0.244), usual walking speed ( r = −0.200), and the Timed Up and Go test ( r = −0.230). Multiple linear regression analysis showed peak VO 2 /HR was an independent determinant of MoCA‐J score after adjusting for potential confounders ( B = 0.424). After 6 months of exercise training with 64 subjects, we found that the per cent change of peak VO 2 /HR was related to the per cent change of MoCA‐J score ( r = 0.296). Conclusions These results suggested that peak VO 2 /HR (an index of stroke volume at peak exercise) might be associated with cognitive impairment based on the vascular cascade hypothesis.