Open AccessSafety and efficacy of antihyperglycaemic agents in diabetic kidney disease
Author(s) -
Niezen Sebastian,
Diaz del Castillo Humberto,
Mendez Castaner Lumen A.,
Fori Alessia
Publication year - 2019
Publication title -
endocrinology, diabetes and metabolism
Language(s) - English
Resource type - Journals
ISSN - 2398-9238
DOI - 10.1002/edm2.72
Subject(s) - medicine , diabetes mellitus , disease , intensive care medicine , kidney disease , blood pressure , end stage renal disease , renin–angiotensin system , endocrinology
Diabetic kidney disease (DKD) is the major contributor to the mortality and the financial burden of diabetes, accounting for approximately 50% of the cases of end‐stage renal disease (ESRD) in the developed world. Several studies have already demonstrated that achieving blood pressure targets in DKD with agents blocking the renin‐angiotensin system confer superior renoprotection when compared to other agents. However, the effects on renal outcomes of antihyperglycaemic agents in these patients have not been reported or studied broadly until recent years. The intent of this article is to review the available data on safety, efficacy, impact on renal outcomes and pathophysiology implications of the most utilized antihyperglycaemic agents in DKD/ESRD.