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Development of network structure and synchronized firing patterns in dissociated culture of neurons
Author(s) -
Kayama Atsushi,
Yada Yuichiro,
Takahashi Hirokazu
Publication year - 2019
Publication title -
electronics and communications in japan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.131
H-Index - 13
eISSN - 1942-9541
pISSN - 1942-9533
DOI - 10.1002/ecj.12199
Subject(s) - hierarchy , biological system , pairwise comparison , biological neural network , connection (principal bundle) , cluster analysis , computer science , biology , artificial intelligence , mathematics , neuroscience , geometry , economics , market economy
Spatiotemporal patterns of neural activities develop repeatability, diversity, and hierarchy. In the present study, we attempted to elucidate how these dynamical properties are associated with a network structure in primary cultures of dissociated neurons. High‐density CMOS electrode array investigated spatiotemporal activity patterns of dissociated neuronal cultures throughout development. Additionally, based on the spatiotemporal patterns in each test culture, a structure of functional network was estimated with transfer entropy in a pairwise manner. Consequently, repeatability increased with connection strength, dispersity, and clustering at the early developmental stage. Subsequently, hierarchy developed with connection strength and dispersity. These results demonstrated that a repertoire of activity patterns developed with some characteristics of network structure.