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Reconstruction of Bursting Activity in Cultured Neuronal Network from State‐Space Model and Leader Spatial Activity Pattern
Author(s) -
YADA YUICHIRO,
KANZAKI RYOHEI,
TAKAHASHI HIROKAZU
Publication year - 2016
Publication title -
electronics and communications in japan
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 0.131
H-Index - 13
eISSN - 1942-9541
pISSN - 1942-9533
DOI - 10.1002/ecj.11905
Subject(s) - bursting , multielectrode array , network model , premovement neuronal activity , non negative matrix factorization , computer science , biological neural network , pattern recognition (psychology) , artificial intelligence , neuroscience , matrix decomposition , microelectrode , physics , biology , machine learning , electrode , quantum mechanics , eigenvalues and eigenvectors
SUMMARY A small subset of neurons, called “leader neurons”, has been assumed as the sources of network bursts in dissociated neuronal cultures. In this paper, we proposed a network burst generation model that a network burst is considered as a sequential transition of spatial activity patterns lead by a “leader pattern”. We recorded spontaneous activities of cultured cortical networks with high‐density CMOS‐based microelectrode arrays. Spatial patterns were extracted from the high‐dimensional recorded data using nonnegative matrix factorization. Then, we hypothesized the state‐space model where the leader pattern served as input and the others served as states, respectively. After estimating the model parameters from the learning data, we attempted to restore the activities of test data with the estimated model. As a result, the spatio‐temporal patterns in network bursts were successfully reconstructed from the model, suggesting that the leader pattern is a crucial predictor of the network burst.